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Anti-beta-Synuclein/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-beta-Synuclein/FITC Conjugated抗体
英文名称: Anti-beta-Synuclein /FITC
抗体货号: YB--20682R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human beta-Synuclein
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Cow, Rabbit, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2020/6/5 10:49:00
详细资料:  实验方法技术资料
浏览人数:1002
诚信指数:10146点
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使用范围:仅限科研使用,不能应用于临床
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上海钰博生物科技有限公司
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上海·上海
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产品详细描述

 Anti-beta-Synuclein/FITC Conjugated抗体

产品编号 YB-20682R-FITC
英文名称 Anti-beta-Synuclein /FITC
中文名称 FITC标记的核突触蛋白-β抗体
别    名 14 kDa brain-specific protein; Beta-synuclein; Phosphoneuroprotein 14; PNP14; Sncb; Synuclein beta; SYUB_HUMAN;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human beta-Synuclein
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Subcellular Location:
Cytoplasm

Tissue Specificity:
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Post-translational modifications:
Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.

Similarity:
Belongs to the synuclein family.

Database links:

Entrez Gene: 6620 Human

Entrez Gene: 104069 Mouse

Entrez Gene: 113893 Rat

Omim: 602569 Human

SwissProt: Q16143 Human

SwissProt: Q91ZZ3 Mouse

SwissProt: Q63754 Rat

Unigene: 90297 Human

Unigene: 200843 Mouse

Unigene: 20352 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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